Fundamental and Development of Microreaction Technology for the Application of Fine Chemicals Synthesis

The fine chemical process has many environmental and safety problems related to the unavoidable use of various organic reactions which are highly involved with exothermic reactions, explosive intermediates, corrosive reagents, toxic or reactive gases, flammable pyrophoric compounds, extreme conditions. Limited by traditional batch process, efficiency these should be manually lowered keep reaction from going out control. Benefiting its rapid transfer heat, efficient micro-mixing ingredients, minimal hold-up hazardous continuous-flow microreaction synthesis emerged as a new technology for producing chemicals efficiently safely in last two decades. Here, we will introduce some recent progress on fundamentals developments efficient, green, safe processes using mainly our group, including rearrangement reaction, cycloaddition diazotization coupling alkylation sulfonation reaction. Based research progress, development was discussed here, applying online analysis intelligent algorithms improve systems lab scale commercial production, extending application solid particle treatment, studying behaviors heterogeneous revealing principles scaling up specialized microreactors, decision toolbox considering both characteristic system overall goal industry.